Sperm DNA fragmentation to predict embryo development, implantation and miscarriage: still an open question

    Rienzi L., Mazzilli R., Ubaldi F.M. Fertil. Steril. 2019 Jul 1. pii: S0015-0282(19)30472-8. doi: 10.1016/j.fertnstert.2019.05.016.


    Male factor infertility is responsible for approximately half of all causes of infertility. In the last decade, more attention has been given to sperm DNA fragmentation (SDF) as a potential cause of unexplained infertility. The increased DNA damage in spermatozoa from men with oligozoospermia seems to be associated with both a reduced chance of natural conception and an increased risk of early pregnancy loss (1). Nevertheless, the role of SDF during in vitro fertilization cycles where intracytoplasmic sperm injection (ICSI) is adopted is still unclear.