Cryostorage management of reproductive cells and tissues in ART: status, needs, opportunities and potential new challenges

Stefano Canosa, Roberta Maggiulli, Danilo Cimadomo, Federica Innocenti, Gemma Fabozzi, Gianluca Gennarelli, Alberto Revelli, Francesca Bongioanni, Alberto Vaiarelli, Flippo M. Ubaldi, Laura Rienzi, Giles A. Palmer, Martine Nijs

RBMO VOLUME 47 ISSUE 3 2023 103252 Published: June 21, 2023 DOI:https://doi.org/10.1016/j.rbmo.2023.06.007

Abstract

Among the wide range of procedures performed by clinical embryologists, the cryopreservation of reproductive cells and tissues represents a fundamental task in the daily routine. Indeed, cryopreservation procedures can be considered a subspecialty of medically assisted reproductive technology (ART), having the same relevance as sperm injection or embryo biopsy for preimplantation genetic testing. However, although a great deal of care has been devoted to optimizing cryopreservation protocols, the same energy has only recently been spent on developing and implementing strategies for the safe and reliable storage and transport of reproductive specimens. Herein, we have summarized the content of the available guidelines, the risks, the needs and the future perspectives regarding the management of cryopreservation biorepositories used in ART.

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